Nicotinamide restores cognition in AD transgenic
mice via a mechanism involving sirtuin inhibition
and selective reduction of Thr231-phosphotau.
Source:http://www.ncbi.nlm....cles/PMC2617713
Cell Life Versus Cell Longevity: The Mysteries Surrounding the NAD+ Precursor Nicotinamide.
" In a similar vein, inhibition of PARP activity by nicotinamide may be critical for disorders such as Alzheimer’s disease.
More recently, sufficient dietary niacin intake examined in a series of patients aged 65 and older has been implicated as a potential factor to protect against the development or
progression of Alzheimer’s disease. "
Source:http://www.ncbi.nlm....cles/PMC2248696
and selective reduction of Thr231-phosphotau.
Source:http://www.ncbi.nlm....cles/PMC2617713
Cell Life Versus Cell Longevity: The Mysteries Surrounding the NAD+ Precursor Nicotinamide.
" In a similar vein, inhibition of PARP activity by nicotinamide may be critical for disorders such as Alzheimer’s disease.
More recently, sufficient dietary niacin intake examined in a series of patients aged 65 and older has been implicated as a potential factor to protect against the development or
progression of Alzheimer’s disease. "
Source:http://www.ncbi.nlm....cles/PMC2248696
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